Across TCGA pan-cancer cohorts, TMEM198 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM198 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM198 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM198 expression acts as an unfavorable survival marker.

UCEC, COAD, and STAD are the cancer types where TMEM198 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
COAD	OS	Median	III,IV	0.054	0.793	<.001	9	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMEM198 tumor-vs-normal RNA expression · all TMEM198 data types