Across TCGA patient cohorts, TMEM198 mutation is significantly associated with the RNA expression of many other genes, with 1,157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM198-associated genes across cancer lineages are RNU6-1290P, PKN3, and TEDC2. Each is linked with TMEM198 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM198-to-partner and partner-to-TMEM198 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM198→partner) and Y-score (partner→TMEM198) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1290P →	+0.229	+4.469	<.001	.006	3	3
UCEC	PKN3 →	+0.865	+2.425	<.001	.002	3	2
UCEC	TEDC2 →	+0.666	+1.928	<.001	.009	3	2
UCEC	NOL9 →	+0.463	+3.625	.003	.001	3	2
UCEC	SLBP →	+0.602	+3.491	.001	.002	3	2
UCEC	H2AZ1 →	+0.608	+1.939	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,157 associations by consensus.

Exploration

TMEM198 survival (RNA) · tumor vs normal (RNA) · all TMEM198 data types