Across TCGA patient cohorts, TMEM198 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM198-associated genes across cancer lineages are TFRC, eIF4G, and ERK2. Each is linked with TMEM198 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM198-to-partner and partner-to-TMEM198 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM198→partner) and Y-score (partner→TMEM198) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.467	+3.000	.044	.036	3	2
UCEC	eIF4G →	+0.294	+3.169	.030	.018	3	1
UCEC	ERK2 →	+0.229	+2.999	.006	.035	3	1
UCEC	p62 Lck ligand →	+0.439	+2.115	.001	.019	3	1
UCEC	PCNA →	+0.339	+2.459	<.001	.018	3	1
UCEC	Annexin-1 →	+0.482	+2.189	.036	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

TMEM198 survival (RNA) · tumor vs normal (RNA) · all TMEM198 data types