Across TCGA cell cohorts, TMEM198 mutation is significantly associated with the RNA expression of many other genes, with 473 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM198-associated genes across cancer lineages are GRK3, CBY1, and MCAT. Each is linked with TMEM198 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM198-to-partner and partner-to-TMEM198 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM198→partner) and Y-score (partner→TMEM198) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRK3 →	+0.911	+3.451	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.657	+3.137	<.001	.007	3	1
LARGE_INTESTINE	MCAT →	+0.808	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TNRC6B →	+0.828	+3.064	<.001	.009	3	1
LARGE_INTESTINE	POLR3H →	+0.819	+3.364	<.001	.002	3	1
LARGE_INTESTINE	DESI1 →	+0.622	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 473 associations by consensus.

Exploration

TMEM198 survival (RNA) · tumor vs normal (RNA) · all TMEM198 data types