TMEM196

Across TCGA pan-cancer cohorts, TMEM196 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM196 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TMEM196 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM196 expression acts as an unfavorable survival marker.

LUAD and LUSC are the cancer types where TMEM196 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.158	0.663	.008	16	view →
LUSC	OS	Median	All	0.314	0.728	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM196–LUAD (OS)

Open the LUAD breakdown →