TMEM196

Across TCGA patient cohorts, TMEM196 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM196-associated genes across cancer lineages are FOXO3a_pS318_S321, Notch1, and p27. Each is linked with TMEM196 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM196-to-partner and partner-to-TMEM196 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TMEM196-low versus TMEM196-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM196→partner) and Y-score (partner→TMEM196) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.130	-2.321	.037	.035	3	1
UCEC	Notch1 →	+0.172	+3.459	.015	.005	3	1
UCEC	p27 →	-0.222	-2.321	.043	.035	3	1
UCEC	Tuberin →	+0.366	+2.179	.006	.034	3	1
UCEC	4E-BP1 →	+0.312	+2.321	.021	.035	3	1
UCEC	Dvl3 →	+0.314	+2.321	<.001	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FOXO3a_pS318_S321 by TMEM196 expression — UCEC

Explore this box plot interactively →