TMEM191B

Across TCGA patient cohorts, TMEM191B RNA expression is significantly associated with the go_rna of many other GO terms, with 6,748 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TMEM191B-associated GO terms across cancer lineages are Positive regulation of sphingolipid biosynthetic process, Nucleoside triphosphate biosynthetic process, and Spermidine metabolic process. Each is linked with TMEM191B in more than 15 cancer types. Because this analysis shows association rather than direction, both TMEM191B-to-partner and partner-to-TMEM191B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of sphingolipid biosynthetic process grouped by TMEM191B-low versus TMEM191B-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM191B→partner) and Y-score (partner→TMEM191B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Positive regulation of sphingolipid biosynthetic process →	+0.046	+0.322	.001	<.001	2	16
UVM	Nucleoside triphosphate biosynthetic process →	+0.023	+0.204	.003	<.001	3	14
LAML	Spermidine metabolic process →	+0.046	+0.261	.002	.001	1	16
READ	tRNA thio-modification →	+0.058	+0.300	<.001	<.001	3	13
READ	Isopentenyl diphosphate biosynthetic process →	+0.048	+0.305	<.001	<.001	3	13
UVM	Proton motive force-driven ATP synthesis →	+0.031	+0.148	.002	.002	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,748 associations by consensus.

Positive regulation of sphingolipid biosynthetic process by TMEM191B expression — PAAD

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