Across TCGA patient cohorts, TMEM191A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM191A-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ER-alpha_pS118. Each is linked with TMEM191A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM191A-to-partner and partner-to-TMEM191A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM191A→partner) and Y-score (partner→TMEM191A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.101	-2.446	.038	.020	3	1
UCEC	EGFR_pY1068 →	-0.240	-3.169	.048	.019	3	1
UCEC	ER-alpha_pS118 →	-0.343	-2.459	.048	.020	3	1
UCEC	ERK2 →	+0.248	+3.169	.007	.019	3	1
UCEC	MEK1 →	+0.365	+2.459	.038	.020	3	1
UCEC	Notch1 →	+0.144	+3.009	.034	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

TMEM191A survival (RNA) · tumor vs normal (RNA) · all TMEM191A data types