TMEM19

Across TCGA pan-cancer cohorts, TMEM19 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM19’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TMEM19 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM19 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

LSCC, COAD, and HNSC are the cancer types where TMEM19 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM19 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.472	<.001	8	view →
COAD	Female	All	−0.268	.004	6	view →
HNSC	Male	All	+0.294	.001	4	view →
CCRCC	All	All	−0.299	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TMEM19–LSCC

Open the LSCC breakdown →