Across TCGA patient cohorts, TMEM185B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM185B-associated genes across cancer lineages are A-Raf_pS299, ERK2, and Gab2. Each is linked with TMEM185B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM185B-to-partner and partner-to-TMEM185B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM185B→partner) and Y-score (partner→TMEM185B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.237	-3.169	<.001	.020	3	1
UCEC	ERK2 →	+0.393	+3.169	<.001	.019	3	1
UCEC	Gab2 →	+0.466	+3.000	.017	.036	3	1
UCEC	GSK3-a-b →	+0.167	+3.169	.024	.020	3	1
UCEC	p21 →	+0.360	+3.013	<.001	.018	3	1
UCEC	p62 Lck ligand →	+0.450	+3.169	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

TMEM185B survival (RNA) · tumor vs normal (RNA) · all TMEM185B data types