TMEM184C

Across TCGA pan-cancer cohorts, TMEM184C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TMEM184C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TMEM184C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM184C is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, HNSC, and OV are the cancer types where TMEM184C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM184C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.605	<.001	8	view →
HNSC	Male	III,IV	+0.541	<.001	8	view →
OV	All	All	+0.707	.029	2	view →
PDAC	Female	II,III,IV	−0.639	.023	2	view →
LSCC	Female	II,III,IV	+0.190	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TMEM184C–LUAD

Open the LUAD breakdown →