TMEM184C

Across TCGA patient cohorts, TMEM184C mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM184C-associated genes across cancer lineages are Notch1, Shc_pY317, and Cyclin-E2. Each is linked with TMEM184C in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM184C-to-partner and partner-to-TMEM184C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TMEM184C-low versus TMEM184C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM184C→partner) and Y-score (partner→TMEM184C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.281	+2.183	<.001	.033	3	2
UCEC	Shc_pY317 →	-0.194	-2.584	.006	.011	3	2
UCEC	Cyclin-E2 →	+0.187	+2.179	.017	.034	3	2
UCEC	EGFR_pY1068 →	-0.297	-3.321	.011	.010	3	1
UCEC	FoxM1 →	+0.365	+3.700	.002	.001	3	1
UCEC	ACC1 →	+0.491	+2.820	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by TMEM184C expression — UCEC

Explore this box plot interactively →