TMEM182

Across TCGA patient cohorts, TMEM182 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM182-associated genes across cancer lineages are ER-alpha_pS118, MEK1, and mTOR_pS2448. Each is linked with TMEM182 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM182-to-partner and partner-to-TMEM182 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by TMEM182-low versus TMEM182-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM182→partner) and Y-score (partner→TMEM182) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ER-alpha_pS118 →	+0.141	+3.000	.045	.035	3	1
UCEC	MEK1 →	+0.377	+2.584	.018	.010	3	1
UCEC	mTOR_pS2448 →	-0.172	-3.156	.008	.018	3	1
UCEC	NDRG1_pT346 →	-0.519	-2.321	.015	.033	3	1
UCEC	Notch1 →	+0.185	+2.115	.002	.019	3	1
UCEC	p27_pT198 →	+0.093	+2.115	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ER-alpha_pS118 by TMEM182 expression — SKCM

Explore this box plot interactively →