TMEM181

Across TCGA patient cohorts, TMEM181 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,321 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TMEM181-associated proteins across cancer lineages are AFDN, SYNJ2, and REPS1. Each is linked with TMEM181 in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM181-to-partner and partner-to-TMEM181 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM181 versus AFDN in BRCA, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM181→partner) and Y-score (partner→TMEM181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AFDN →	+0.345	+0.663	.004	.001	3	6
GBM	SYNJ2 →	+0.321	+0.389	.001	<.001	3	5
GBM	REPS1 →	+0.219	+0.552	.002	<.001	3	5
LSCC	ARID1B →	+0.209	+0.316	<.001	.003	3	5
LSCC	PARP10 →	-0.285	-0.445	.002	<.001	3	4
GBM	PDCD2 →	+0.319	+0.446	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,321 associations by consensus.

TMEM181 vs AFDN — BRCA

Explore this scatter interactively →