TMEM181

Across TCGA patient cohorts, TMEM181 protein abundance is significantly associated with the RNA expression of many other genes, with 7,421 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMEM181-associated genes across cancer lineages are PSTPIP1, TCP1, and SERAC1. Each is linked with TMEM181 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM181-to-partner and partner-to-TMEM181 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM181 versus PSTPIP1 in HNSC, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM181→partner) and Y-score (partner→TMEM181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSTPIP1 →	-0.652	-0.299	<.001	<.001	3	5
LSCC	TCP1 →	+0.571	+0.254	<.001	.001	3	4
GBM	SERAC1 →	+0.698	+0.516	<.001	<.001	3	4
HNSC	WDFY4 →	-0.891	-0.359	<.001	<.001	3	4
GBM	TULP4 →	+0.860	+0.522	<.001	<.001	3	4
HNSC	SIGLEC10 →	-0.778	-0.369	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,421 associations by consensus.

TMEM181 vs PSTPIP1 — HNSC

Explore this scatter interactively →