TMEM181

Across TCGA patient cohorts, TMEM181 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM181-associated genes across cancer lineages are ATM, EGFR_pY1068, and ERK2. Each is linked with TMEM181 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM181-to-partner and partner-to-TMEM181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TMEM181-low versus TMEM181-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM181→partner) and Y-score (partner→TMEM181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.715	-2.321	.001	.034	3	2
UCEC	EGFR_pY1068 →	-0.256	-3.000	.034	.036	3	1
UCEC	ERK2 →	+0.286	+2.459	.002	.020	3	1
UCEC	MSH6 →	-0.357	-2.990	.025	.036	3	1
UCEC	mTOR_pS2448 →	-0.150	-2.980	.037	.036	3	1
UCEC	Src_pY527 →	-0.437	-2.459	.035	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ATM by TMEM181 expression — UCEC

Explore this box plot interactively →