TMEM181

Across TCGA cell cohorts, TMEM181 mutation is significantly associated with the drug of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM181-associated genes across cancer lineages are GW-2580, 5-Fluorouracil, and Vinorelbine. Each is linked with TMEM181 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM181-to-partner and partner-to-TMEM181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GW-2580 grouped by TMEM181-low versus TMEM181-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM181→partner) and Y-score (partner→TMEM181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GW-2580 →	+0.323	+3.008	.007	.016	3	2
LARGE_INTESTINE	5-Fluorouracil →	+0.681	+2.807	.008	.037	3	1
LARGE_INTESTINE	Vinorelbine →	+0.673	+3.000	.025	.021	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.465	+2.874	.038	.021	3	1
LARGE_INTESTINE	ETP-45835 →	+0.294	+2.874	.009	.021	3	1
LARGE_INTESTINE	ARRY-520 →	+0.703	+2.807	.047	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GW-2580 by TMEM181 expression — LARGE_INTESTINE

Explore this box plot interactively →