TMEM18

Across TCGA patient cohorts, TMEM18 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,153 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM18-associated proteins across cancer lineages are EPS15_S221, C1orf162_S112, and C5orf24. Each is linked with TMEM18 in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM18-to-partner and partner-to-TMEM18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM18 versus EPS15_S221 in GBM, with a Pearson correlation of -0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM18→partner) and Y-score (partner→TMEM18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EPS15_S221 →	-0.328	-0.231	<.001	<.001	3	6
HNSC	C1orf162_S112 →	-0.770	-0.706	.001	.005	3	5
OV	C5orf24 →	+0.318	+0.397	<.001	<.001	3	5
GBM	STX11 →	-0.782	-0.338	<.001	<.001	3	5
GBM	VEZF1 →	+0.544	+0.398	<.001	<.001	3	5
PDAC	YWHAQ →	+0.323	+0.247	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,153 associations by consensus.

TMEM18 vs EPS15_S221 — GBM

Explore this scatter interactively →