TMEM18

Across TCGA patient cohorts, TMEM18 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM18-associated genes across cancer lineages are Astrocytes, Melanocytes, and Megakaryocytes. Each is linked with TMEM18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM18-to-partner and partner-to-TMEM18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocytes grouped by TMEM18-low versus TMEM18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM18→partner) and Y-score (partner→TMEM18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Astrocytes →	+0.056	+3.410	.005	.014	3	2
UCEC	Melanocytes →	-0.011	-2.268	.045	.036	3	2
UCEC	Megakaryocytes →	-0.029	-2.279	.017	.036	1	1
UCEC	Mesangial cells →	-0.065	-3.448	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Astrocytes by TMEM18 expression — SKCM

Explore this box plot interactively →