TMEM177

Across TCGA cell cohorts, TMEM177 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,837 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM177-associated GO terms across cancer lineages are Mitochondrial large ribosomal subunit assembly, Ribosomal large subunit assembly, and Ribosome assembly. Each is linked with TMEM177 in more than 16 cancer types. Because this analysis shows association rather than direction, both TMEM177-to-partner and partner-to-TMEM177 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial large ribosomal subunit assembly grouped by TMEM177-low versus TMEM177-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM177→partner) and Y-score (partner→TMEM177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Mitochondrial large ribosomal subunit assembly →	+0.136	+0.826	<.001	<.001	3	17
BONE	Ribosomal large subunit assembly →	+0.160	+1.103	<.001	.001	3	16
BONE	Ribosome assembly →	+0.103	+1.020	.002	.008	3	15
URINARY_TRACT	IMP biosynthetic process →	+0.202	+0.833	.002	.002	3	15
BONE	rRNA processing →	+0.142	+1.049	<.001	.006	3	15
BONE	rRNA metabolic process →	+0.134	+1.248	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,837 associations by consensus.

Mitochondrial large ribosomal subunit assembly by TMEM177 expression — BLOOD_Lymphoma

Explore this box plot interactively →