TMEM177

Across TCGA cell cohorts, TMEM177 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TMEM177-associated genes across cancer lineages are GSG1L2, IQCF5, and TNP2. Each is linked with TMEM177 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM177-to-partner and partner-to-TMEM177 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by TMEM177-low versus TMEM177-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM177→partner) and Y-score (partner→TMEM177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.026	+6.022	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	TNP2 →	+0.031	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	GALP →	+0.610	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GSG1L2 by TMEM177 expression — LARGE_INTESTINE

Explore this box plot interactively →