TMEM176B

Across TCGA pan-cancer cohorts, TMEM176B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM176B data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TMEM176B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TMEM176B expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where TMEM176B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	1.000	0.625	.012	5	view →
PDAC	OS	Median	All	0.871	0.486	.040	4	view →
CCRCC	OS	Tertile	III,IV	0.259	0.978	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM176B–LSCC (OS)

Open the LSCC breakdown →