TMEM176B

Across TCGA pan-cancer cohorts, TMEM176B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TMEM176B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TMEM176B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM176B is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

LSCC, HNSC, and CCRCC are the cancer types where TMEM176B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM176B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	+0.538	<.001	8	view →
HNSC	All	II,III,IV	+0.347	.002	8	view →
CCRCC	All	All	−0.230	.001	8	view →
LUAD	Male	All	+0.527	<.001	7	view →
COAD	Male	IV	−0.560	.029	4	view →
OV	All	All	−1.512	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TMEM176B–LSCC

Open the LSCC breakdown →