TMEM176B

Across TCGA patient cohorts, TMEM176B protein abundance is significantly associated with the RNA expression of many other genes, with 10,934 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM176B-associated genes across cancer lineages are TMEM176A, CSF2RB, and ARHGAP9. Each is linked with TMEM176B in more than 6 cancer types. Because this analysis shows association rather than direction, both TMEM176B-to-partner and partner-to-TMEM176B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM176B versus TMEM176A in UCEC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176B→partner) and Y-score (partner→TMEM176B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM176A →	+1.414	+1.027	.001	.006	3	7
UCEC	CSF2RB →	+1.079	+0.795	.004	.005	3	5
UCEC	ARHGAP9 →	+1.062	+1.046	.002	.003	3	5
GBM	IL2RA →	+1.454	+0.422	<.001	<.001	3	5
UCEC	STX11 →	+0.828	+0.898	<.001	.001	3	5
UCEC	SLA →	+1.550	+1.108	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,934 associations by consensus.

TMEM176B vs TMEM176A — UCEC

Explore this scatter interactively →