TMEM176B

Across TCGA patient cohorts, TMEM176B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM176B-associated genes across cancer lineages are S6_pS240_S244, Smad4, and Bcl-2. Each is linked with TMEM176B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM176B-to-partner and partner-to-TMEM176B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by TMEM176B-low versus TMEM176B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176B→partner) and Y-score (partner→TMEM176B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	S6_pS240_S244 →	-0.452	-2.321	.023	.033	3	1
SKCM	Smad4 →	+0.137	+2.841	.011	.033	3	1
SKCM	Bcl-2 →	+0.351	+2.459	.041	.020	3	1
UCEC	A-Raf_pS299 →	-0.179	-3.169	.002	.019	3	1
UCEC	ERK2 →	+0.216	+3.169	.026	.019	3	1
UCEC	JNK2 →	+0.336	+2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

S6_pS240_S244 by TMEM176B expression — SKCM

Explore this box plot interactively →