TMEM176B

Across TCGA cell cohorts, TMEM176B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM176B-associated GO terms across cancer lineages are Negative regulation of dendritic cell differentiation, Regulation of syncytium formation by plasma membrane fusion, and Mitochondrial electron transport, ubiquinol to cytochrome c. Each is linked with TMEM176B in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM176B-to-partner and partner-to-TMEM176B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dendritic cell differentiation grouped by TMEM176B-low versus TMEM176B-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176B→partner) and Y-score (partner→TMEM176B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of dendritic cell differentiation →	+2.183	+4.001	<.001	<.001	3	12
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.089	+3.295	<.001	<.001	3	7
LUNG_SCLC	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.083	+3.053	.001	<.001	3	7
LUNG_SCLC	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.043	-2.604	<.001	<.001	3	7
LUNG_SCLC	Regulation of cardiocyte differentiation →	-0.106	-2.603	.001	.007	3	6
LIVER	Monocarboxylic acid catabolic process →	+0.070	+3.417	.003	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,132 associations by consensus.

Negative regulation of dendritic cell differentiation by TMEM176B expression — LARGE_INTESTINE

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