TMEM176B

Across TCGA cell cohorts, TMEM176B mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM176B-associated genes across cancer lineages are FHL5, MBD3L5, and SCYGR10. Each is linked with TMEM176B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM176B-to-partner and partner-to-TMEM176B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FHL5 grouped by TMEM176B-low versus TMEM176B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176B→partner) and Y-score (partner→TMEM176B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FHL5 →	+0.162	+4.415	<.001	.007	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
SKIN	SCYGR10 →	+0.176	+4.684	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FHL5 by TMEM176B expression — SKIN

Explore this box plot interactively →