TMEM176A

Across TCGA pan-cancer cohorts, TMEM176A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM176A data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TMEM176A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM176A expression acts as an unfavorable survival marker.

SCLC, COAD, and SKCM are the cancer types where TMEM176A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
COAD	DFS	Median	II,III,IV	0.074	0.744	<.001	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM176A–SCLC (OS)

Open the SCLC breakdown →