TMEM176A

Across TCGA pan-cancer cohorts, TMEM176A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM176A data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM176A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM176A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where TMEM176A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.216	1.000	.010	12	view →
CCRCC	OS	Median	III,IV	1.000	0.820	.015	3	view →
LSCC	OS	Median	All	0.839	0.684	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM176A–HNSC (OS)

Open the HNSC breakdown →