TMEM176A

Across TCGA patient cohorts, TMEM176A mutation is significantly associated with the RNA expression of many other genes, with 734 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM176A-associated genes across cancer lineages are RN7SL219P, NUDT5, and POP7. Each is linked with TMEM176A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM176A-to-partner and partner-to-TMEM176A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL219P grouped by TMEM176A-low versus TMEM176A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176A→partner) and Y-score (partner→TMEM176A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL219P →	+0.335	+2.920	.004	.004	3	2
SKCM	NUDT5 →	+0.422	+2.076	<.001	.001	3	2
SKCM	POP7 →	+0.383	+3.267	<.001	<.001	3	2
SKCM	MRPS11 →	+0.308	+1.999	.001	.009	3	2
SKCM	NF2 →	+0.337	+2.945	.006	<.001	3	2
SKCM	TUBAP2 →	+0.348	+2.389	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 734 associations by consensus.

RN7SL219P by TMEM176A expression — UCEC

Explore this box plot interactively →