TMEM176A

Across TCGA patient cohorts, TMEM176A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM176A-associated genes across cancer lineages are p27_pT157, Acetyl-a-Tubulin-Lys40, and p21. Each is linked with TMEM176A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM176A-to-partner and partner-to-TMEM176A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by TMEM176A-low versus TMEM176A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176A→partner) and Y-score (partner→TMEM176A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p27_pT157 →	+0.172	+1.700	<.001	.043	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.595	+3.321	.025	.010	3	1
SKCM	p21 →	-0.589	-3.000	.001	.034	3	1
SKCM	AMPK_alpha →	+0.168	+2.321	.004	.033	3	1
SKCM	CD20 →	+0.121	+3.012	.038	.018	3	1
UCEC	c-Jun_pS73 →	-0.178	-3.321	.032	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p27_pT157 by TMEM176A expression — SKCM

Explore this box plot interactively →