TMEM176A

Across TCGA cell cohorts, TMEM176A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,235 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM176A-associated GO terms across cancer lineages are Negative regulation of dendritic cell differentiation, Serotonin biosynthetic process, and Adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Each is linked with TMEM176A in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM176A-to-partner and partner-to-TMEM176A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dendritic cell differentiation grouped by TMEM176A-low versus TMEM176A-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176A→partner) and Y-score (partner→TMEM176A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of dendritic cell differentiation →	+2.232	+4.125	<.001	<.001	3	11
LUNG_SCLC	Serotonin biosynthetic process →	+1.325	+3.852	<.001	<.001	3	7
LUNG_SCLC	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.050	-4.522	<.001	<.001	3	6
BONE	Detoxification of copper ion →	-0.340	-1.357	<.001	.008	3	6
BONE	Stress response to copper ion →	-0.340	-1.357	<.001	.008	3	6
LIVER	Regulation of cytotoxic T cell degranulation →	+1.655	+2.988	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,235 associations by consensus.

Negative regulation of dendritic cell differentiation by TMEM176A expression — LARGE_INTESTINE

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