TMEM176A

Across TCGA cell cohorts, TMEM176A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM176A-associated genes across cancer lineages are GTSF1L, PTCHD3, and KRT82. Each is linked with TMEM176A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM176A-to-partner and partner-to-TMEM176A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTSF1L grouped by TMEM176A-low versus TMEM176A-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM176A→partner) and Y-score (partner→TMEM176A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GTSF1L →	+0.030	+4.781	<.001	.003	3	1
BREAST	PTCHD3 →	+0.328	+4.421	<.001	.004	3	1
LUNG_NSCLC_LUAD	KRT82 →	+0.036	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	KRTAP4-4 →	+0.015	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	CATSPERD →	+0.068	+3.906	<.001	.002	3	1
LUNG_NSCLC_LUAD	FOXR1 →	+0.079	+3.832	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GTSF1L by TMEM176A expression — BREAST

Explore this box plot interactively →