TMEM175

Across TCGA pan-cancer cohorts, TMEM175 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TMEM175 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TMEM175 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM175 expression acts as an unfavorable survival marker.

THYM, HNSC, and KICH are the cancer types where TMEM175 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	OS	Median	All	0.202	0.686	.008	36	view →
KICH	DFS	Median	All	0.081	0.904	<.001	30	view →
STAD	OS	Median	III,IV	0.152	0.633	<.001	18	view →
LIHC	DFS	Median	II,III,IV	0.045	0.414	<.001	12	view →
SKCM	OS	Median	II,III,IV	0.325	0.740	.004	7	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	All	0.254	0.673	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TMEM175–THYM (OS)

Open the THYM breakdown →