TMEM175

Across TCGA patient cohorts, TMEM175 mutation is significantly associated with the RNA expression of many other genes, with 3,342 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM175-associated genes across cancer lineages are MIR6877, NF1P10, and PHKG1P1. Each is linked with TMEM175 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM175-to-partner and partner-to-TMEM175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6877 grouped by TMEM175-low versus TMEM175-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM175→partner) and Y-score (partner→TMEM175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR6877 →	+0.532	+5.878	<.001	.002	3	3
CESC	NF1P10 →	+0.097	+4.247	<.001	.007	3	3
BLCA	PHKG1P1 →	+0.082	+5.618	<.001	.002	3	3
BLCA	LINC02155 →	+0.113	+6.307	<.001	<.001	3	2
CESC	TOMM22P4 →	+0.079	+4.020	<.001	.009	3	2
CESC	RNA5SP402 →	+0.244	+3.786	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,342 associations by consensus.

MIR6877 by TMEM175 expression — LIHC

Explore this box plot interactively →