TMEM175

Across TCGA patient cohorts, TMEM175 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM175-associated genes across cancer lineages are GAPDH, ATM, and p62 Lck ligand. Each is linked with TMEM175 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM175-to-partner and partner-to-TMEM175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by TMEM175-low versus TMEM175-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM175→partner) and Y-score (partner→TMEM175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.571	+3.584	.012	.002	3	3
UCEC	ATM →	-0.891	-3.794	<.001	<.001	3	3
UCEC	p62 Lck ligand →	+0.361	+2.222	.009	.011	3	2
UCEC	TFRC →	+0.585	+2.321	.009	.034	3	2
UCEC	eEF2 →	+0.391	+2.906	.010	.001	3	1
UCEC	eIF4E →	+0.188	+2.222	.036	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GAPDH by TMEM175 expression — UCEC

Explore this box plot interactively →