TMEM175

Across TCGA cell cohorts, TMEM175 mutation is significantly associated with the RNA expression of many other genes, with 407 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM175-associated genes across cancer lineages are RAB3A, CCSAP, and FBXW10. Each is linked with TMEM175 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM175-to-partner and partner-to-TMEM175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB3A grouped by TMEM175-low versus TMEM175-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM175→partner) and Y-score (partner→TMEM175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAB3A →	+1.007	+3.386	<.001	.001	3	2
LARGE_INTESTINE	CCSAP →	+0.536	+2.502	.006	.005	3	2
LARGE_INTESTINE	FBXW10 →	+0.182	+2.906	.001	.001	3	2
BREAST	OR10T2 →	+0.091	+3.781	<.001	.009	3	2
BLOOD_Myeloma	IFNA5 →	+0.024	+3.906	<.001	.009	3	1
BLOOD_Myeloma	ALKAL1 →	+0.062	+4.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 407 associations by consensus.

RAB3A by TMEM175 expression — LARGE_INTESTINE

Explore this box plot interactively →