TMEM175

Across TCGA cell cohorts, TMEM175 mutation is significantly associated with the mutation status of many other genes, with 4,777 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM175-associated genes across cancer lineages are ZNF423, MXRA5, and ABCA2. Each is linked with TMEM175 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM175-to-partner and partner-to-TMEM175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF423 grouped by TMEM175-low versus TMEM175-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM175→partner) and Y-score (partner→TMEM175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF423 →	+5.115	+5.115	.005	.005	1	5
BLOOD_Leukemia	MXRA5 →	+1.861	+2.198	.003	.003	1	5
LARGE_INTESTINE	ABCA2 →	+1.919	+2.921	<.001	<.001	1	5
BREAST	TICRR →	+2.974	+3.169	.003	.003	1	5
BREAST	CFB →	+3.389	+3.389	.001	.001	1	5
BREAST	MYH4 →	+4.295	+4.295	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,777 associations by consensus.

ZNF423 by TMEM175 expression — PANCREAS

Explore this box plot interactively →