Across TCGA cell cohorts, TMEM170B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,405 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM170B-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Negative regulation of RNA export from nucleus, and Regulation of DNA repair. Each is linked with TMEM170B in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM170B-to-partner and partner-to-TMEM170B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM170B→partner) and Y-score (partner→TMEM170B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.067	+1.181	.002	<.001	3	12
BONE	Negative regulation of RNA export from nucleus →	+0.160	+1.528	<.001	<.001	3	12
BONE	Regulation of DNA repair →	+0.057	+1.146	<.001	<.001	3	12
STOMACH	Regulation of potassium ion transmembrane transport →	-0.136	-0.975	.003	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of muscle contraction →	-0.099	-0.383	.001	.006	3	11
BONE	Positive regulation of double-strand break repair via homologous recombination →	+0.126	+1.500	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,405 associations by consensus.

Exploration

TMEM170B survival (RNA) · tumor vs normal (RNA) · all TMEM170B data types