Across TCGA patient cohorts, TMEM17 protein abundance is significantly associated with the RNA expression of many other genes, with 5,062 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM17-associated genes across cancer lineages are KRT8P40, PRRC2C, and DCAF8. Each is linked with TMEM17 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM17-to-partner and partner-to-TMEM17 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM17→partner) and Y-score (partner→TMEM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KRT8P40 →	+0.363	+0.365	<.001	<.001	3	2
HNSC	PRRC2C →	+0.619	+0.637	.002	.001	3	2
HNSC	DCAF8 →	+0.839	+0.876	<.001	.004	3	2
HNSC	POGK →	+0.538	+0.637	<.001	.001	3	2
HNSC	POU2F1 →	+0.800	+0.876	.002	.004	3	2
HNSC	FAM122B →	+1.753	+0.876	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,062 associations by consensus.

Exploration

TMEM17 survival (RNA) · tumor vs normal (RNA) · all TMEM17 data types