Across TCGA patient cohorts, TMEM17 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM17-associated genes across cancer lineages are PCNA, STAT3_pY705, and mTOR. Each is linked with TMEM17 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM17-to-partner and partner-to-TMEM17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM17→partner) and Y-score (partner→TMEM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.242	+3.169	.041	.020	3	1
UCEC	STAT3_pY705 →	-0.375	-3.169	.009	.020	3	1
UCEC	mTOR →	-0.252	-3.169	.004	.020	1	1
UCEC	Notch1 →	+0.199	+3.169	.009	.020	1	1
UCEC	TSC1 →	-0.309	-3.169	<.001	.020	1	1
UCEC	ATM →	-0.760	-3.169	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TMEM17 survival (RNA) · tumor vs normal (RNA) · all TMEM17 data types