Across TCGA patient cohorts, TMEM167B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM167B-associated genes across cancer lineages are Ku80, PCNA, and SLC1A5. Each is linked with TMEM167B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM167B-to-partner and partner-to-TMEM167B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM167B→partner) and Y-score (partner→TMEM167B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.294	+3.013	.031	.019	3	1
UCEC	PCNA →	+0.260	+3.000	.037	.037	3	1
UCEC	SLC1A5 →	-0.551	-2.992	.024	.036	3	1
UCEC	VHL →	-0.856	-3.000	.029	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.711	+3.000	.038	.037	3	1
UCEC	Caspase-8 →	-0.324	-3.000	.026	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TMEM167B survival (RNA) · tumor vs normal (RNA) · all TMEM167B data types