TMEM167B-DT

Across TCGA pan-cancer cohorts, TMEM167B-DT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM167B-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM167B-DT RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM167B-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where TMEM167B-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM167B-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.591	<.001	10	view →
THCA	Male	All	−0.991	<.001	10	view →
COAD	All	IV	−0.501	.001	8	view →
LIHC	All	II,III,IV	+0.445	<.001	8	view →
KIRC	Male	II,III,IV	−0.456	<.001	7	view →
BLCA	Male	III,IV	−0.532	.015	4	view →
CHOL	All	All	+0.810	.004	2	view →
PRAD	All	All	+0.259	<.001	2	view →
LUAD	All	IV	+0.110	.038	2	view →
READ	All	II,III,IV	−0.217	.013	1	view →
LUSC	All	All	+0.165	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM167B-DT–KICH

Open the KICH breakdown →