TMEM165

Across TCGA patient cohorts, TMEM165 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM165-associated genes across cancer lineages are MIR6853, CHCHD2P11, and MIR6864. Each is linked with TMEM165 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM165-to-partner and partner-to-TMEM165 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6853 grouped by TMEM165-low versus TMEM165-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM165→partner) and Y-score (partner→TMEM165) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
UCEC	CHCHD2P11 →	+0.350	+2.758	.003	.008	3	1
UCEC	MIR6864 →	+0.763	+3.546	<.001	<.001	3	1
UCEC	MIR4662B →	+0.286	+4.069	<.001	.008	3	1
UCEC	MIR3944 →	+0.435	+2.882	<.001	.004	3	1
UCEC	RNU6-879P →	+0.465	+2.903	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MIR6853 by TMEM165 expression — BRCA

Explore this box plot interactively →