TMEM163

Across TCGA patient cohorts, TMEM163 mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM163-associated genes across cancer lineages are RNU6-645P, KRTAP12-3, and ARPC1BP1. Each is linked with TMEM163 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM163-to-partner and partner-to-TMEM163 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-645P grouped by TMEM163-low versus TMEM163-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM163→partner) and Y-score (partner→TMEM163) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-645P →	+1.025	+4.790	<.001	.006	3	2
COAD	KRTAP12-3 →	+0.243	+6.020	<.001	<.001	3	2
COAD	ARPC1BP1 →	+0.342	+4.478	<.001	.005	3	2
COAD	PTPRT-AS1 →	+0.555	+5.917	<.001	.001	3	2
COAD	TOR1BP1 →	+0.181	+4.602	.002	.008	3	2
COAD	LARP7P4 →	+0.577	+6.142	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

RNU6-645P by TMEM163 expression — COAD

Explore this box plot interactively →