TMEM163

Across TCGA patient cohorts, TMEM163 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TMEM163-associated genes across cancer lineages are Monocytes, Tregs, and CD4+ T-cells. Each is linked with TMEM163 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM163-to-partner and partner-to-TMEM163 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by TMEM163-low versus TMEM163-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM163→partner) and Y-score (partner→TMEM163) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Monocytes →	+0.017	+5.149	<.001	.036	3	1
COAD	Tregs →	+0.061	+4.824	<.001	.045	3	1
COAD	CD4+ T-cells →	+0.037	+6.156	<.001	.018	3	1
UCEC	Megakaryocytes →	-0.024	-2.072	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Monocytes by TMEM163 expression — COAD

Explore this box plot interactively →