TMEM163

Across TCGA cell cohorts, TMEM163 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM163-associated genes across cancer lineages are CLLU1-AS1, NAT8B, and NCR2. Each is linked with TMEM163 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM163-to-partner and partner-to-TMEM163 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLLU1-AS1 grouped by TMEM163-low versus TMEM163-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM163→partner) and Y-score (partner→TMEM163) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CLLU1-AS1 →	+0.052	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUAD	NAT8B →	+0.042	+4.371	.005	.005	3	1
LUNG_NSCLC_LUAD	NCR2 →	+0.014	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CLLU1-AS1 by TMEM163 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →