TMEM161B

Across TCGA patient cohorts, TMEM161B mutation is significantly associated with the RNA expression of many other genes, with 3,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM161B-associated genes across cancer lineages are RTCB, POLDIP3, and C1QBP. Each is linked with TMEM161B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM161B-to-partner and partner-to-TMEM161B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTCB grouped by TMEM161B-low versus TMEM161B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM161B→partner) and Y-score (partner→TMEM161B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RTCB →	+0.529	+2.375	<.001	<.001	3	2
UCEC	POLDIP3 →	+0.526	+2.042	<.001	<.001	3	2
UCEC	C1QBP →	+0.517	+2.458	<.001	.001	3	2
UCEC	COQ6 →	+0.252	+2.510	<.001	.001	3	2
UCEC	PCMT1 →	+0.417	+2.010	.002	<.001	3	2
UCEC	UBIAD1 →	+0.452	+1.716	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,229 associations by consensus.

RTCB by TMEM161B expression — UCEC

Explore this box plot interactively →