TMEM161B

Across TCGA patient cohorts, TMEM161B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM161B-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Src_pY416. Each is linked with TMEM161B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM161B-to-partner and partner-to-TMEM161B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM161B-low versus TMEM161B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM161B→partner) and Y-score (partner→TMEM161B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.210	-2.584	.015	.010	3	2
UCEC	ERK2 →	+0.183	+1.906	.006	.015	3	2
UCEC	Src_pY416 →	-0.191	-1.700	.022	.042	3	2
UCEC	ATM →	-0.508	-2.070	.001	.001	3	2
UCEC	Cyclin-B1 →	+0.641	+2.070	<.001	.001	3	2
UCEC	eIF4G →	+0.275	+2.000	.010	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by TMEM161B expression — UCEC

Explore this box plot interactively →