TMEM161B

Across TCGA cell cohorts, TMEM161B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,291 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM161B-associated GO terms across cancer lineages are Target-directed miRNA degradation, Protein localization to site of double-strand break, and Establishment of protein localization to vacuole. Each is linked with TMEM161B in more than 13 cancer types. Because this analysis shows association rather than direction, both TMEM161B-to-partner and partner-to-TMEM161B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Target-directed miRNA degradation grouped by TMEM161B-low versus TMEM161B-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM161B→partner) and Y-score (partner→TMEM161B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Target-directed miRNA degradation →	+0.107	+0.685	.004	.002	3	14
PANCREAS	Protein localization to site of double-strand break →	+0.093	+0.930	<.001	<.001	3	14
BREAST	Establishment of protein localization to vacuole →	+0.065	+0.761	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.061	+1.075	.002	<.001	3	12
SOFT_TISSUE	Centrosome cycle →	+0.085	+0.669	<.001	<.001	3	12
BREAST	Protein targeting to vacuole →	+0.076	+0.755	<.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,291 associations by consensus.

Target-directed miRNA degradation by TMEM161B expression — BLOOD_Myeloma

Explore this box plot interactively →